Cytotoxic sigma-2 ligands trigger cancer cell death via cholesterol-induced-ER-stress
By Rony Takchi, Bethany C. Prudner, Qingqing Gong, Takaomi Hagi, Kenneth F. Newcomer, Linda X. Jin, Suwanna Vangveravong, Brian A. Van Tine, William G. Hawkins, and Dirk Spitzer Excerpt from the article published in Cell Death & Disease volume 15, Article number: 309, 02 May 2024, DOI: https://doi.org/10.1038/s41419-024-06693-8 Abstract Sigma-2-ligands (S2L) are characterized by high […]
Continue ReadingTMEM97/Sigma 2 Receptor Increases Estrogen Receptor α Activity in Promoting Breast Cancer Cell Growth
By Yuanqin Zhang, Xiangwei Fang, Jiuhui Wang and Daotai Nie Excerpt from the article published in Cancers 2023, 15(23): 5691. 2 December 2023. DOI: https://doi.org/10.3390/cancers15235691 Editor’s Highlitghts Simple Summary Selective estrogen receptor modulators are a major treatment modality for estrogen receptor-positive breast cancers, but the emergence of resistance or a lack of initial responsiveness is a […]
Continue ReadingSigma1 Regulates Lipid Droplet–Mediated Redox Homeostasis Required for Prostate Cancer Proliferation
By Halley M. Oyer; Alexandra R. Steck; Charles G. Longen; Sanjana Venkat; Konuralp Bayrak; Eleanor B. Munger; Dan Fu; Paola A. Castagnino; Christina M. Sanders; Nathalia A. Tancler; My T. Mai; Justin P. Myers; Matthew J. Schiewer; Nan Chen; Elahe A. Mostaghel; and Felix J. Kim Excerpt from the article published in Cancer Research Communications (October […]
Continue ReadingSigma Receptors: Novel Regulators of Iron/Heme Homeostasis and Ferroptosis
By Nhi T. Nguyen, Valeria Jaramillo-Martinez, Marilyn Mathew, Varshini V. Suresh, Sathish Sivaprakasam, Yangzom D. Bhutia, and Vadivel Ganapathy Excerpt from the article published in International Journal of Molecular Sciences. 28 September 2023; 24(19):14672. DOI: https://doi.org/10.3390/ijms241914672 Editor’s Higlights Abstract Sigma receptors are non-opiate/non-phencyclidine receptors that bind progesterone and/or heme and also several unrelated xenobiotics/chemicals. They […]
Continue ReadingAn Emerging Role for Sigma Receptor 1 in Personalized Treatment of Breast Cancer
By Taylor S. Robinson and Mahasin A. Osman Excerpt from the article published in Cancers, 2 July 2023, 15, 3464. DOI: https://doi.org/10.3390/cancers15133464 Editor’s Highlights Simple Summary Breast cancer continues to be the number one cause of cancer mortality among women. Because breast cancer is a heterogenous disease there is a need for a more personalized approach to […]
Continue ReadingBS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting
By Claudia Sorbi, Silvia Belluti, Claudio Giacinto Atene, Federica Marocchi, Pasquale Linciano, Neena Roy, Elia Paradiso, Livio Casarini, Simone Ronsisvalle, Tommaso Zanocco-Marani, Livio Brasili, Luisa Lanfrancone, Carol Imbriano, Giulia Di Rocco, and Silvia Franchini Excerpt from the article published in the International Journal of Molecular Sciences. 2 June 2023; 24(11):9684. DOI: https://doi.org/10.3390/ijms24119684 Editor’s Highlights Abstract […]
Continue ReadingSig1R activates extracellular matrix-induced bladder cancer cell proliferation and angiogenesis by combing β-integrin
By Feng Zhao, Tianli Yang, Liuhua Zhou, Rongfei Li, Jingyu Liu, Jun Zhao, and Ruipeng Jia Excerpt from the article published in Aging (Albany NY). 2023 May 16; DOI: https://doi.org/10.18632/aging.204721 Editor’s Highlights Abstract The extracellular matrix (ECM) regulates many biological functions involved in tumorigenesis and tumor development; however, the underlying mechanism remains unknown. Sigma 1 […]
Continue ReadingAutophagy and Breast Cancer: Connected in Growth, Progression, and Therapy
By Qitong Wu and Dipali Sharma Excerpt from the article published in Cells. 14 April 2023; 12(8):1156. DOI: https://doi.org/10.3390/cells12081156 Editor’s Highlights Abstract Despite an increase in the incidence of breast cancer worldwide, overall prognosis has been consistently improving owing to the development of multiple targeted therapies and novel combination regimens including endocrine therapies, aromatase inhibitors, […]
Continue ReadingSigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97
By Bashar M. Thejer, Vittoria Infantino, Anna Santarsiero, Ilaria Pappalardo, Francesca S. Abatematteo, Sarah Teakel, Ashleigh Van Oosterum, Robert H. Mach, Nunzio Denora, Byung Chul Lee, Nicoletta Resta, Rosanna Bagnulo, Mauro Niso, Marialessandra Contino, Bianca Montsch, Petra Heffeter, Carmen Abate, and Michael A. Cahill Excerpt from the article published in the International Journal of Molecular […]
Continue ReadingRole of the Ca2+ channel α2δ-1 auxiliary subunit in proliferation and migration of human glioblastoma cells
By Miriam Fernández-Gallardo, Alejandra Corzo-Lopez, David Muñoz-Herrera, Margarita Leyva-Leyva, Ricardo González-Ramírez, Alejandro Sandoval, Rodolfo Delgado-Lezama, Eduardo Monjaraz, and Ricardo Felix Excerpt from the article published in PLoS ONE 17(12): e0279186, December 15, 2022, DOI: https://doi.org/10.1371/journal.pone.0279186 Editor’s Highlights Abstract The overexpression of α2δ-1 is related to the development and degree of malignancy of diverse types of […]
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