Category Archives: Cancer

TMEM97/Sigma 2 Receptor Increases Estrogen Receptor α Activity in Promoting Breast Cancer Cell Growth

TMEM97/Sigma 2 Receptor Increases Estrogen Receptor α Activity in Promoting Breast Cancer Cell Growth

By Yuanqin Zhang, Xiangwei Fang, Jiuhui Wang and Daotai Nie Excerpt from the article published in Cancers 2023, 15(23): 5691. 2 December 2023. DOI: https://doi.org/10.3390/cancers15235691 Editor’s Highlitghts Simple Summary Selective estrogen receptor modulators are a major treatment modality for estrogen receptor-positive breast cancers, but the emergence of resistance or a lack of initial responsiveness is a […]

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Sigma Receptors: Novel Regulators of Iron/Heme Homeostasis and Ferroptosis

Sigma Receptors: Novel Regulators of Iron/Heme Homeostasis and Ferroptosis

By Nhi T. Nguyen, Valeria Jaramillo-Martinez, Marilyn Mathew, Varshini V. Suresh, Sathish Sivaprakasam, Yangzom D. Bhutia, and Vadivel Ganapathy Excerpt from the article published in International Journal of Molecular Sciences.  28 September 2023; 24(19):14672. DOI: https://doi.org/10.3390/ijms241914672 Editor’s Higlights Abstract Sigma receptors are non-opiate/non-phencyclidine receptors that bind progesterone and/or heme and also several unrelated xenobiotics/chemicals. They […]

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An Emerging Role for Sigma Receptor 1 in Personalized Treatment of Breast Cancer

An Emerging Role for Sigma Receptor 1 in Personalized Treatment of Breast Cancer

By Taylor S. Robinson and Mahasin A. Osman Excerpt from the article published in Cancers, 2 July 2023, 15, 3464. DOI: https://doi.org/10.3390/cancers15133464 Editor’s Highlights Simple Summary Breast cancer continues to be the number one cause of cancer mortality among women. Because breast cancer is a heterogenous disease there is a need for a more personalized approach to […]

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BS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting

BS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting

By Claudia Sorbi, Silvia Belluti, Claudio Giacinto Atene, Federica Marocchi, Pasquale Linciano, Neena Roy, Elia Paradiso, Livio Casarini, Simone Ronsisvalle, Tommaso Zanocco-Marani, Livio Brasili, Luisa Lanfrancone, Carol Imbriano, Giulia Di Rocco, and Silvia Franchini Excerpt from the article published in the International Journal of Molecular Sciences. 2 June 2023; 24(11):9684. DOI: https://doi.org/10.3390/ijms24119684 Editor’s Highlights Abstract […]

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Sig1R activates extracellular matrix-induced bladder cancer cell proliferation and angiogenesis by combing β-integrin

Sig1R activates extracellular matrix-induced bladder cancer cell proliferation and angiogenesis by combing β-integrin

By Feng Zhao, Tianli Yang, Liuhua Zhou, Rongfei Li, Jingyu Liu, Jun Zhao, and Ruipeng Jia Excerpt from the article published in Aging (Albany NY). 2023 May 16; DOI: https://doi.org/10.18632/aging.204721 Editor’s Highlights Abstract The extracellular matrix (ECM) regulates many biological functions involved in tumorigenesis and tumor development; however, the underlying mechanism remains unknown. Sigma 1 […]

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Autophagy and Breast Cancer: Connected in Growth, Progression, and Therapy

Autophagy and Breast Cancer: Connected in Growth, Progression, and Therapy

By Qitong Wu and Dipali Sharma Excerpt from the article published in Cells. 14 April 2023; 12(8):1156. DOI: https://doi.org/10.3390/cells12081156 Editor’s Highlights Abstract Despite an increase in the incidence of breast cancer worldwide, overall prognosis has been consistently improving owing to the development of multiple targeted therapies and novel combination regimens including endocrine therapies, aromatase inhibitors, […]

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Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97

Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97

By Bashar M. Thejer, Vittoria Infantino, Anna Santarsiero, Ilaria Pappalardo, Francesca S. Abatematteo, Sarah Teakel, Ashleigh Van Oosterum, Robert H. Mach, Nunzio Denora, Byung Chul Lee, Nicoletta Resta, Rosanna Bagnulo, Mauro Niso, Marialessandra Contino, Bianca Montsch, Petra Heffeter, Carmen Abate, and Michael A. Cahill Excerpt from the article published in the International Journal of Molecular […]

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Role of the Ca2+ channel α2δ-1 auxiliary subunit in proliferation and migration of human glioblastoma cells

Role of the Ca2+ channel α2δ-1 auxiliary subunit in proliferation and migration of human glioblastoma cells

By Miriam Fernández-Gallardo, Alejandra Corzo-Lopez, David Muñoz-Herrera, Margarita Leyva-Leyva, Ricardo González-Ramírez, Alejandro Sandoval, Rodolfo Delgado-Lezama, Eduardo Monjaraz, and Ricardo Felix Excerpt from the article published in PLoS ONE 17(12): e0279186, December 15, 2022, DOI: https://doi.org/10.1371/journal.pone.0279186 Editor’s Highlights Abstract The overexpression of α2δ-1 is related to the development and degree of malignancy of diverse types of […]

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Incorporation of a selective sigma-2 receptor ligand enhances uptake of liposomes by multiple cancer cells

Incorporation of a selective sigma-2 receptor ligand enhances uptake of liposomes by multiple cancer cells

By Yifei Zhang, Yixian Huang, Peng Zhang, Xiang Gao, Robert B Gibbs, and Song Li Excerpt from the article published in International Journal of Nanomedicine, 7: 4473-4485, 07 Dec 2022, DOI: 10.2147/IJN.S31981 Editor’s Highlights Abstract Background: The sigma-2 receptor is an attractive target for tumor imaging and targeted therapy because it is overexpressed in multiple types of solid tumors, […]

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