Cal‘MAM’ity at the Endoplasmic Reticulum-Mitochondrial Interface: A Potential Therapeutic Target for Neurodegeneration and Human Immunodeficiency Virus-Associated Neurocognitive Disorders
By Jessica Proulx, In-Woo Park, and Kathleen Borgmann Excerpt from the article published in Frontiers in neuroscience, 15, 715945. https://doi.org/10.3389/fnins.2021.715945 Editor’s Highlights Cooperation and communication between the ER and mitochondria are essential to ensure maintenance of neuronal and organelle homeostasis. Neurons are not directly infected by HIV-1; thus, indirect HIV-induced toxicity via infected glia is a key mechanism […]
Continue ReadingInvolvement of Sigma Receptor-1 in Lymphatic Endothelial Barrier Integrity and Bioenergetic Regulation
By Zeinab Y. Motawe, Salma S. Abdelmaboud, and Jerome W. Breslin Excerpt from the article published in Lymphatic Research and Biology.Jun 2021.231-239. http://doi.org/10.1089/lrb.2020.0060 Editor’s Highlights The lymphatic system has an important role in fluid homeostasis, lymph transport, lipid trafficking, and immunity. Lymphatic function starts in the vast networks of lymphatic capillaries (also termed initial lymphatic […]
Continue ReadingSigma-1 Receptor Engages an Anti-Inflammatory and Antioxidant Feedback Loop Mediated by Peroxiredoxin in Experimental Colitis
By Nikoletta Almási, Török Szilvia, Zsuzsanna Valkusz, Máté Tajti, Ákos Csonka, Zsolt Murlasits, Anikó Pósa, Csaba Varga, and Krisztina Kupai. Excerpt from the article published in Antioxidants 9, no. 11: 1081. 2020; Doi: https://doi.org/10.3390/antiox9111081 Editor’s Highlights Inflammatory bowel disease (IBD) is a chronic, remitting, and relapsing ailment of the gastrointestinal (GI) tract. Prolonged oxidative stress impairs […]
Continue ReadingSigma-1 receptor is involved in diminished ovarian reserve possibly by influencing endoplasmic reticulum stress-mediated granulosa cells apoptosis
By Lile Jiang, Jinquan Cui, Cuilian Zhang, Juanke Xie, Shaodi Zhang, Dongjun Fu, and Wei Duo Excerpt from the article published in Aging (Albany NY). 2020; 12:9041-9065. https://doi.org/10.18632/aging.103166 Editor’s Highlights Infertility is a common disease and affects more than 15% of reproductive-age couples. Diminished ovarian reserve (DOR) is found in approximately 10% of infertile women. […]
Continue ReadingHigh-throughput screening discovers antifibrotic properties of haloperidol by hindering myofibroblast activation
By Michael Rehman, Simone Vodret, Luca Braga, Corrado Guarnaccia, Fulvio Celsi, Giulia Rossetti, Valentina Martinelli, Tiziana Battini, Carlin Long, Kristina Vukusic, Tea Kocijan, Chiara Collesi, Nadja Ring, Natasa Skoko, Mauro Giacca, Giannino Del Sal, Marco Confalonieri, Marcello Raspa, Alessandro Marcello, Michael P. Myers, Sergio Crovella, Paolo Carloni, and Serena Zacchigna Excerpt from the article published […]
Continue ReadingModulation of the Sigma-1 Receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis.
By Dorian A Rosen, Scott M. Seki, Anthony Fernández-Castañeda, Rebecca M. Beiter, Jacob D. Eccles, Judith A. Woodfolk, and Alban Gaultier Excerpt from the author manuscript published in Science translational medicine, 2019 Feb 6; 11(478): eaau5266. available here https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936250/#!po=28.9474 Editor’s Highlights The endoplasmic reticulum (ER) is increasingly recognized as a powerful controller of inflammatory signaling and […]
Continue ReadingSmall-Molecule Sigma1 Modulator Induces Autophagic Degradation of PD-L1
By Christina M. Maher; Jeffrey D. Thomas; Derick A. Haas; Charles G. Longen; Halley M. Oyer; Jane Y. Tong; and Felix J. Kim Excerpt from the article published in Molecular Cancer Research, Volume 16, Issue 2; 1 February 2018; 243–255; DOI: https://doi.org/10.1158/1541-7786.MCR-17-0166 Editor’s Highlights Abstract Emerging evidence suggests that Sigma1 (SIGMAR1, also known as sigma-1 […]
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