A Non-Canonical Role for IRE1α Links ER and Mitochondria as Key Regulators of Astrocyte Dysfunction: Implications in Methamphetamine use and HIV-Associated Neurocognitive Disorders
By Jessica Proulx, Satomi Stacy, In-Woo Park, and Kathleen Borgmann Excerpt from the article published in Frontiers in Neuroscience, 16, 17 June 2022, DOI https://doi.org/10.3389/fnins.2022.906651 Editor’s Highlights During human immunodeficiency virus (HIV)-1 infection or (METH)amphetamine exposure, astrocytes shift their neuroprotective functions and can become neurotoxic. As common comorbidity among HIV-1 infected individuals (METH)amphetamine use can […]
Continue ReadingSigma-1 receptor attenuates osteoclastogenesis by promoting ER-associated degradation of SERCA2
By Xiaoan Wei, Zeyu Zheng, Zhenhua Feng, Lin Zheng, Siyue Tao, Bingjie Zheng, Bao Huang, Xuyang Zhang, Junhui Liu, Yilei Chen, Wentian Zong, Zhi Shan, Shunwu Fan, Jian Chen, and Fengdong Zhao Excerpt from the article published in EMBO Molecular Medicine e15373 25 May 2022 DOI: https://doi.org/10.15252/emmm.202115373 Editor’s Highlights Abstract Sigma-1 receptor (Sigmar1) is a […]
Continue ReadingCellular interorganelle crosstalk in health and disease states: A glimpse on nephrology-related conditions
By Fateme Shamekhi Amiri Excerpt from the article published in Archives of Clinical Nephrology 8(1): 007-027. DOI: 10.17352/acn.000059 Editor’s Highlights Mitochondria as a signalling organelle associates with the cellular signalling environment and mediates gene expression programs. Mitochondria are constantly interacting with other organelles through signalling pathways, and on some occasions even though physical contact sites. Sigma-1receptor […]
Continue ReadingBromodomains in Human-Immunodeficiency Virus-Associated Neurocognitive Disorders: A Model of Ferroptosis-Induced Neurodegeneration
By Adonis Sfera, Karina G. Thomas, Christina V. Andronescu, Nyla Jafri, Dan O.Sfera, Sarvin Sasannia, Carlos M. Zapata-Martín del Campo, and Jose C. Maldonado Excerpt from the article published in Frontiers in Neuroscience, volume 16, 2022, https://www.frontiersin.org/article/10.3389/fnins.2022.904816 DOI=10.3389/fnins.2022.904816 Editor’s Highlights Memory and behavioral dysfunction can occur in up to 50% of Human immunodeficiency virus (HIV) […]
Continue ReadingRapid Molecular Diagnosis of Genetically Inherited Neuromuscular Disorders Using Next-Generation Sequencing Technologies
By Sofia Barbosa-Gouveia, Maria Eugenia Vázquez-Mosquera, Emiliano González-Vioque, Álvaro Hermida-Ameijeiras, Paula Sánchez-Pintos, Maria José de Castro, Soraya Ramiro León, Belén Gil-Fournier, Cristina Domínguez-González, Ana Camacho Salas, Luis Negrão, Isabel Fineza, Francisco Laranjeira, and Maria Luz Couce Excerpt from the article published in Journal of Clinical Medicine 11, no. 10: 2750. 12 May 2022 https://doi.org/10.3390/jcm11102750 Editor’s Highlights […]
Continue ReadingThe ER-Mitochondria Interface as a Dynamic Hub for T Cell Efficacy in Solid Tumors
By Elizabeth G. Hunt, Alex M. Andrews, Sydney R. Larsen, and Jessica E. Thaxton Excerpt from the article published in Frontiers in Cell and Developmental Biology, volume 10, 27 April 2022 | https://doi.org/10.3389/fcell.2022.867341 Editor’s Highlights T cells are an immune subset exhibiting robust dependence on ER and mitochondrial function based on the need for protein synthesis and […]
Continue ReadingSigma‑1 receptor overexpression promotes proliferation and ameliorates cell apoptosis in β‑cells
By Mengting Ke, Fengping Lin, Huawei Wang, Guangzhen He, Jieyuan Feng, Linyang Song, Yancheng Xu, and Jie Liu Excerpt from the article published in Molecular Medicine Reports 25, no. 5 (2022): 170. https://doi.org/10.3892/mmr.2022.12686 Editor’s Highlights Sigma-1 receptor (Sig-1R) is a class of receptors that serve unique physiological functions due to the lack of homology with […]
Continue ReadingImpact of history of mental disorders on short-term mortality among hospitalized patients with sepsis: A population-based cohort study
By Lavi Oud, and John Garza Excerpt from the article published in PLoS ONE 17(3): e0265240. Published: March 10, 2022, DOI: https://doi.org/10.1371/journal.pone.0265240 Editor’s Highlights Sepsis remains a major global health burden with estimated nearly 49 million cases worldwide in 2017 and 11 million sepsis-related deaths. Mental disorders were associated, unexpectedly, with markedly lower risk of […]
Continue ReadingZC3H4 promotes pulmonary fibrosis via an ER stress-related positive feedback loop
By Hammad Ghafoor, Han Chu, Jie Huang, Mengling Chen, Sha Wang, Jing Wang, and Jie Chao Excerpt from the article published in Toxicology and Applied Pharmacology, Volume 435, 2022, 115856, ISSN 0041-008X, https://doi.org/10.1016/j.taap.2021.115856 Editor’s Highlights ZC3H4 directly interacts with the Sigmar1 protein in the pulmonary fibroblast activation. Silicosis is a type of pulmonary fibrosis caused by […]
Continue ReadingSigma-1 Receptor is a Pharmacological Target to Promote Neuroprotection in the SOD1G93A ALS Mice
By Núria Gaja-Capdevila, Neus Hernández, Xavier Navarro, and Mireia Herrando-Grabulosa Excerpt from the article published in Frontiers in Pharmacology, 10 December 2021 | https://doi.org/10.3389/fphar.2021.780588 Editor’s Highlights Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive loss of upper and lower motoneurons (MNs), causing muscle paralysis and early death. The etiology underlying the […]
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