Aging is associated with increased brain iron through cortex-derived hepcidin expression
By Tatsuya Sato, Jason Solomon Shapiro, Hsiang-Chun Chang, Richard A Miller, and Hossein Ardehali Excerpt from the article published in eLife 11:e73456. DOI: https://doi.org/10.7554/eLife.73456 Editor’s Highlights Iron is critical for normal cell function, but its excess can lead to cellular damage due to oxidative stress. Iron accumulates in the brain cortex with aging and that this […]
Continue ReadingCellular senescence links mitochondria-ER contacts and aging
By Dorian V. Ziegler, Nadine Martin, and David Bernard Excerpt from the article published in Communications Biology 4, 1323 (2021). DOI: https://doi.org/10.1038/s42003-021-02840-5 Editor’s Highlights Endoplasmic reticulum (ER) and mitochondria constitute two key organelles involved in macromolecules synthesis and bioenergetics, but also in stress sensing and integration of cell fate signaling. ER and mitochondria interact with each other […]
Continue ReadingAging with Down Syndrome—Where Are We Now and Where Are We Going?
by Melissa J. Alldred, Alessandra C. Martini, David Patterson, James Hendrix, and Ann-Charlotte Granholm Excerpt from the article published in Journal of Clinical Medicine 10, no. 20: 4687. 13 October 2021 DOI: https://doi.org/10.3390/jcm10204687 Abstract Down syndrome (DS) is a form of accelerated aging, and people with DS are highly prone to aging-related conditions that include vascular […]
Continue ReadingThe Unfolded Protein Response in Immune Cells as an Emerging Regulator of Neuroinflammation
By Dominique Fernández, Antonia Geisse, Jose Ignacio Bernales, Alonso Lira, and Fabiola Osorio Excerpt from the article published in Frontiers of Aging Neuroscience, 11 June 2021, Sec. Cellular and Molecular Mechanisms of Brain-aging, DOI: https://doi.org/10.3389/fnagi.2021.682633 Editor’s Highlights Cells possess regulatory mechanisms that maintain proteostasis in conditions that overload the folding capacity of the organelle (a […]
Continue ReadingInterorganelle communication, aging, and neurodegeneration
By Maja Petkovic, Caitlin E. O’Brien, and Yuh Nung Jan Excerpt from the article published in Genes & Dev. 2021. 35: 449-469 PMCID: PMC8015714 DOI: 10.1101/gad.346759.120 Editor’s Highlights Cellular organelles and their associated processes do not function in isolation, but within a robust cellular communication network—the cellular communicome—to maintain homeostasis. Many proteins participate at multiple distinct contact sites between different […]
Continue ReadingTargeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control
By Maria Cavinato, Corina T. Madreiter-Sokolowski, Sabrina Büttner, Markus Schosserer, Werner Zwerschke, Sophia Wedel, Johannes Grillari, Wolfgang F. Graier, and Pidder Jansen-Dürr Excerpt from the article published in The FEBS Journal, 17 November 2020, DOI: https://doi.org/10.1111/febs.15631 Editor’s Highlights Aging is a complex process driving progressive decline of functionality and regenerative potential of tissues. During aging, […]
Continue ReadingSigma‐1 receptor protects against ferroptosis in hepatocellular carcinoma cells
By Tao Bai, Pengxu Lei, Hao Zhou, Ruopeng Liang, Rongtao Zhu, Weijie Wang, Lin Zhou, and Yuling Sun Excerpt from the article published in Journal of Cellular and Molecular Medicine 2019 Nov; 23(11): 7349–7359. DOI: 10.1111/jcmm.14594 Editor’s Highlights Hepatocellular carcinoma (HCC) is a common type of cancer that is ranked sixth in prevalence and third in mortality worldwide. […]
Continue ReadingCardiac 11C-Donepezil Binding Increases With Age in Healthy Humans: Potentially Signifying Sigma-1 Receptor Upregulation
By Jacob Horsager, Tatyana D. Fedorova, Nathalie V.D. Berge, Mette W. Klinge, Karoline Knudsen, Allan K. Hansen, Aage K.O. Alstrup, Klaus Krogh, Lars Gormsen, and Per Borghammer Excerpt from the article published in Journal of Cardiovascular Pharmacology and Therapeutics. July 2019:365-370. doi: 10.1177/1074248419838509 Editor’s Highlights Sigma-1 receptors (S1Rs) are upregulated in the heart in response […]
Continue ReadingTargeting the Endoplasmic Reticulum Unfolded Protein Response to Counteract the Oxidative Stress-Induced Endothelial Dysfunction
By Giuseppina Amodio, Ornella Moltedo, Raffaella Faraonio, and Paolo Remondelli Excerpt from the article published in Oxidative Medicine and Cellular Longevity, vol. 2018, Article ID 4946289, 13 pages, 14 Mar 2018. DOI: https://doi.org/10.1155/2018/4946289 Editor’s Highlights Abstract In endothelial cells, the tight control of the redox environment is essential for the maintenance of vascular homeostasis. The […]
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