Novel compound inhibits glycolysis, proteotoxicity, inflammation, and impairments in animal models of Alzheimer’s, Huntington’s, and stroke: Aging as a consequence of glycolysis
By Rachel Litke, Kun-Hyung Roh, Yonejung Yoon, Sindhu Vangeti, Irene Ramos-lopez, Husnu Kaniskan, Jian Jin, Christopher Kellner, and Charles Mobbs Excerpt from the article published in bioRxiv 2023.06.12, 544352; doi: https://doi.org/10.1101/2023.06.12.544352 Editor’s Highlights Abstract Alzheimer’s Disease (AD) and other age-related diseases are increasingly among the most devastating strains on public health systems as the population ages, yet […]
Continue ReadingSigma 1 receptor activation improves retinal structure and function in the RhoP23H/+ mouse model of autosomal dominant retinitis pigmentosa
By Shannon R. Barwick, Haiyan Xiao, David Wolff, Jing Wang, Elizabeth Perry, Brendan Marshall, and Sylvia B. Smith Extract from the article published in Experimental Eye Research, Volume 230, May 2023, 109462, ISSN 0014-4835, DOI: https://doi.org/10.1016/j.exer.2023.109462 Editor’s Highlights Abstract Retinitis pigmentosa (RP) is a group of devastating inherited retinal diseases that leads to visual impairment and oftentimes complete blindness. Currently no […]
Continue ReadingAntipsychotics function as epigenetic age regulators in human neuroblastoma cells
By Jianbin Du, Yutaka Nakachi, Ayaka Fujii, Shinya Fujii, Miki Bundo, and Kazuya Iwamoto Excerpt from the article published in Schizophrenia 8, 69, 29 August 2022. DOI: https://doi.org/10.1038/s41537-022-00277-1 Editor’s Highlights Schizophrenia is proposed to be a syndrome of accelerated aging in the body, which is partly the cause of the shortened lifespan of patients with schizophrenia. […]
Continue ReadingAdenosine A2A receptors control synaptic remodeling in the adult brain
By Xinli Xu, Rui O. Beleza, Francisco Q. Gonçalves, Sergio Valbuena, Sofia Alçada-Morais, Nélio Gonçalves, Joana Magalhães, João M. M. Rocha, Sofia Ferreira, Ana S. G. Figueira, Juan Lerma, Rodrigo A. Cunha, Ricardo J. Rodrigues, and Joana M. Marques Excerpt from the article published in Scientific Reports 12, 14690, 29 August 2022, DOI: https://doi.org/10.1038/s41598-022-18884-4 Editor’s […]
Continue ReadingMitochondria-Associated Endoplasmic Reticulum Membranes: Inextricably Linked with Autophagy Process
By Chonghao Ji, Zhanwei Zhang, Zechuan Li, Xiao She, Xiaoya Wang, Binyang Li, Xin Xu, Dawei Song, and Dongjiao Zhang Excerpt from the article published in Oxidative Medicine and Cellular Longevity (Hindawi), Volume 2022, 23 Aug 2022, Article ID 7086807, DOI: https://doi.org/10.1155/2022/7086807 Editor’s Highlights There is a growing body of evidence indicating Mitochondria-associated membranes (MAMs) act as […]
Continue ReadingActivation of the sigma-1 receptor exerts cardioprotection in a rodent model of chronic heart failure by stimulation of angiogenesis
By Xin Zhao, Xin Liu, Xiuhuan Chen, Xueyu Han, Yazhou Sun, Yuhong Fo, Xiukun Wang, Chuan Qu, and Bo Yang Excerpt from the article published in Molecular Medicine volume 28, Article number: 87, 03 August 2022, DOI: https://doi.org/10.1186/s10020-022-00517-1 Editor’s Highlights With the increase of global aging population, the incidence of Heart Failure (HF) has increased […]
Continue ReadingPGRMC1 Regulates Cellular Senescence via Modulating FOXO1 Expression in Decidualizing Endometrial Stromal Cells
By Atsuya Tsuru, Mikihiro Yoshie, Junya Kojima, Ryo Yonekawa, Mana Azumi, Kazuya Kusama, Hirotaka Nishi, and Kazuhiro Tamura Excerpt from the article published in Biomolecules 2022, 12, 1046, 28 July 2022, DOI: https://doi.org/10.3390/biom12081046 Editor’s Highlights The differentiation of endometrial stromal cells (ESCs) into decidual cells is essential for the acquisition of endometrial receptivity for implantation and subsequent […]
Continue ReadingMitochondrial dysfunction in cell senescence and aging
By Satomi Miwa, Sonu Kashyap, Eduardo Chini, and Thomas von Zglinicki Excerpt from the article in Journal of Clinical Investigation 2022;132(13):e158447. Published July 1, 2022, DOI: https://doi.org/10.1172/JCI158447. Editor’s Highlights Mitochondrial dysfunction in aging tissues and senescent cells is a decrease in respiratory capacity per mitochondrion together with a decreased mitochondrial membrane potential (MMP) at steady […]
Continue ReadingProteostasis collapse is a driver of cell aging and death
By Mantu Santra, Ken A. Dill, and Adam M. R. de Graff Excerpt from the article published in PNAS, 116(44) 22173-22178, October 16, 2019, DOI: https://doi.org/10.1073/pnas.1906592116 Editor’s Highlights Aging results from declining protein quality-control systems involved in protein synthesis, degradation, and chaperoning that normally protect the proteins in the cell’s proteome Proteostasis, the decline in protein […]
Continue ReadingProtein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration
By Verena Kluever, Belisa Russo, Sunit Mandad, Nisha Hemandhar Kumar, Mihai Alevra, Alessandro Ori, Silvio O. Rizzoli, Henning Urlaub, Anja Schneider, and Eugenio F. Fornasiero Excerpt from the article published in Science Advances, 20 May 2022, Vol 8, Issue 20 DOI: 10.1126/sciadv.abn4437 Editor’s Highlights Physiologically aged brain has revealed only minor alterations in protein abundances in the aged […]
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