Sigma and Autoimmune diseases

Published research to date related to Sigma proteins and Autoimmune diseases has been conducted with compounds not developed by Advantx Pharmaceuticals Inc. Our therapeutic candidates are the first truly selective, pharmaceutical-grade compounds in development targeting Sigma receptors with clean molecules and unambiguous activity, far superior in potency, selectivity, safety and efficacy to all others tested to date.


A Non-Canonical Role for IRE1α Links ER and Mitochondria as Key Regulators of Astrocyte Dysfunction: Implications in Methamphetamine use and HIV-Associated Neurocognitive Disorders

By Jessica Proulx, Satomi Stacy, In-Woo Park, and Kathleen Borgmann Excerpt from the article published in Frontiers in Neuroscience, 16, 17 June 2022, DOI Editor’s Highlights During human immunodeficiency virus (HIV)-1 infection or (METH)amphetamine exposure, astrocytes shift their neuroprotective functions and can become neurotoxic. As common comorbidity among HIV-1 infected individuals (METH)amphetamine use can […]

Sigma-1 receptor attenuates osteoclastogenesis by promoting ER-associated degradation of SERCA2

By Xiaoan Wei, Zeyu Zheng, Zhenhua Feng, Lin Zheng, Siyue Tao, Bingjie Zheng, Bao Huang, Xuyang Zhang, Junhui Liu, Yilei Chen, Wentian Zong, Zhi Shan, Shunwu Fan, Jian Chen, and Fengdong Zhao Excerpt from the article published in EMBO Molecular Medicine e15373 25 May 2022 DOI: Editor’s Highlights Abstract Sigma-1 receptor (Sigmar1) is a […]

Cellular interorganelle crosstalk in health and disease states: A glimpse on nephrology-related conditions

By Fateme Shamekhi Amiri Excerpt from the article published in Archives of Clinical Nephrology 8(1): 007-027. DOI: 10.17352/acn.000059 Editor’s Highlights Mitochondria as a signalling organelle associates with the cellular signalling environment and mediates gene expression programs. Mitochondria are constantly interacting with other organelles through signalling pathways, and on some occasions even though physical contact sites. Sigma-1receptor […]

Bromodomains in Human-Immunodeficiency Virus-Associated Neurocognitive Disorders: A Model of Ferroptosis-Induced Neurodegeneration

By Adonis Sfera, Karina G. Thomas, Christina V. Andronescu, Nyla Jafri, Dan O.Sfera, Sarvin Sasannia, Carlos M. Zapata-Martín del Campo, and Jose C. Maldonado Excerpt from the article published in Frontiers in Neuroscience, volume 16, 2022, DOI=10.3389/fnins.2022.904816 Editor’s Highlights Memory and behavioral dysfunction can occur in up to 50% of Human immunodeficiency virus (HIV) […]

Rapid Molecular Diagnosis of Genetically Inherited Neuromuscular Disorders Using Next-Generation Sequencing Technologies

By Sofia Barbosa-Gouveia, Maria Eugenia Vázquez-Mosquera, Emiliano González-Vioque, Álvaro Hermida-Ameijeiras, Paula Sánchez-Pintos, Maria José de Castro, Soraya Ramiro León, Belén Gil-Fournier, Cristina Domínguez-González, Ana Camacho Salas, Luis Negrão, Isabel Fineza, Francisco Laranjeira, and Maria Luz Couce Excerpt from the article published in Journal of Clinical Medicine 11, no. 10: 2750. 12 May 2022 Editor’s Highlights […]

The ER-Mitochondria Interface as a Dynamic Hub for T Cell Efficacy in Solid Tumors

By Elizabeth G. Hunt, Alex M. Andrews, Sydney R. Larsen, and Jessica E. Thaxton Excerpt from the article published in Frontiers in Cell and Developmental Biology, volume 10, 27 April 2022 | Editor’s Highlights T cells are an immune subset exhibiting robust dependence on ER and mitochondrial function based on the need for protein synthesis and […]

Sigma‑1 receptor overexpression promotes proliferation and ameliorates cell apoptosis in β‑cells

By Mengting Ke, Fengping Lin, Huawei Wang, Guangzhen He, Jieyuan Feng, Linyang Song, Yancheng Xu, and Jie Liu Excerpt from the article published in Molecular Medicine Reports 25, no. 5 (2022): 170. Editor’s Highlights Sigma-1 receptor (Sig-1R) is a class of receptors that serve unique physiological functions due to the lack of homology with […]

Impact of history of mental disorders on short-term mortality among hospitalized patients with sepsis: A population-based cohort study

By Lavi Oud, and John Garza Excerpt from the article published in PLoS ONE 17(3): e0265240. Published: March 10, 2022, DOI: Editor’s Highlights Sepsis remains a major global health burden with estimated nearly 49 million cases worldwide in 2017 and 11 million sepsis-related deaths. Mental disorders were associated, unexpectedly, with markedly lower risk of […]

ZC3H4 promotes pulmonary fibrosis via an ER stress-related positive feedback loop

By Hammad Ghafoor, Han Chu, Jie Huang, Mengling Chen, Sha Wang, Jing Wang, and Jie Chao Excerpt from the article published in Toxicology and Applied Pharmacology, Volume 435, 2022, 115856, ISSN 0041-008X, Editor’s Highlights ZC3H4 directly interacts with the Sigmar1 protein in the pulmonary fibroblast activation. Silicosis is a type of pulmonary fibrosis caused by […]

Sigma-1 Receptor is a Pharmacological Target to Promote Neuroprotection in the SOD1G93A ALS Mice

By Núria Gaja-Capdevila, Neus Hernández, Xavier Navarro, and Mireia Herrando-Grabulosa Excerpt from the article published in Frontiers in Pharmacology, 10 December 2021 | Editor’s Highlights Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive loss of upper and lower motoneurons (MNs), causing muscle paralysis and early death.  The etiology underlying the […]

Cal‘MAM’ity at the Endoplasmic Reticulum-Mitochondrial Interface: A Potential Therapeutic Target for Neurodegeneration and Human Immunodeficiency Virus-Associated Neurocognitive Disorders

By Jessica Proulx, In-Woo Park, and Kathleen Borgmann Excerpt from the article published in Frontiers in neuroscience, 15, 715945. Editor’s Highlights Cooperation and communication between the ER and mitochondria are essential to ensure maintenance of neuronal and organelle homeostasis. Neurons are not directly infected by HIV-1; thus, indirect HIV-induced toxicity via infected glia is a key mechanism […]

Involvement of Sigma Receptor-1 in Lymphatic Endothelial Barrier Integrity and Bioenergetic Regulation

By Zeinab Y. Motawe, Salma S. Abdelmaboud, and Jerome W. Breslin Excerpt from the article published in Lymphatic Research and Biology.Jun 2021.231-239. Editor’s Highlights The lymphatic system has an important role in fluid homeostasis, lymph transport, lipid trafficking, and immunity. Lymphatic function starts in the vast networks of lymphatic capillaries (also termed initial lymphatic […]

Sigma-1 Receptor Engages an Anti-Inflammatory and Antioxidant Feedback Loop Mediated by Peroxiredoxin in Experimental Colitis

By Nikoletta Almási, Török Szilvia, Zsuzsanna Valkusz, Máté Tajti, Ákos Csonka, Zsolt Murlasits, Anikó Pósa, Csaba Varga, and Krisztina Kupai. Excerpt from the article published in Antioxidants 9, no. 11: 1081. 2020; Doi: Editor’s Highlights Inflammatory bowel disease (IBD) is a chronic, remitting, and relapsing ailment of the gastrointestinal (GI) tract.  Prolonged oxidative stress impairs […]

Sigma-1 receptor is involved in diminished ovarian reserve possibly by influencing endoplasmic reticulum stress-mediated granulosa cells apoptosis

By Lile Jiang, Jinquan Cui, Cuilian Zhang, Juanke Xie, Shaodi Zhang, Dongjun Fu, and Wei Duo Excerpt from the article published in Aging (Albany NY). 2020; 12:9041-9065. Editor’s Highlights Infertility is a common disease and affects more than 15% of reproductive-age couples. Diminished ovarian reserve (DOR) is found in approximately 10% of infertile women. […]

High-throughput screening discovers antifibrotic properties of haloperidol by hindering myofibroblast activation

By Michael Rehman, Simone Vodret, Luca Braga, Corrado Guarnaccia, Fulvio Celsi, Giulia Rossetti, Valentina Martinelli, Tiziana Battini, Carlin Long, Kristina Vukusic, Tea Kocijan, Chiara Collesi, Nadja Ring, Natasa Skoko, Mauro Giacca, Giannino Del Sal, Marco Confalonieri, Marcello Raspa, Alessandro Marcello, Michael P. Myers, Sergio Crovella, Paolo Carloni, and Serena Zacchigna Excerpt from the article published […]

Modulation of the Sigma-1 Receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis.

By Dorian A Rosen, Scott M. Seki, Anthony Fernández-Castañeda, Rebecca M. Beiter, Jacob D. Eccles, Judith A. Woodfolk, and Alban Gaultier Excerpt from the author manuscript published in Science translational medicine, 2019 Feb 6; 11(478): eaau5266. available here!po=28.9474 Editor’s Highlights The endoplasmic reticulum (ER) is increasingly recognized as a powerful controller of inflammatory signaling and […]

Small-Molecule Sigma1 Modulator Induces Autophagic Degradation of PD-L1

By Christina M. Maher; Jeffrey D. Thomas; Derick A. Haas; Charles G. Longen; Halley M. Oyer; Jane Y. Tong; and Felix J. Kim Excerpt from the article published in Molecular Cancer Research, Volume 16, Issue 2; 1 February 2018; 243–255; DOI: Editor’s Highlights Abstract Emerging evidence suggests that Sigma1 (SIGMAR1, also known as sigma-1 […]