The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor complex are responsible for the cellular uptake of Aβ42 and its protein aggregates
By Aladdin Riad, Zsofia Lengyel-Zhand, Chenbo Zeng, Chi-Chang Weng, Virginia M.-Y. Lee, John Q. Trojanowski, and Robert H. Mach Excerpt from the article published in Molecular Neurobiology 2020 Sep; 57(9): 3803–3813. Published online 2020 Jun 23. doi: 10.1007/s12035-020-01988-1 Abstract Background: Our lab has recently shown that the Sigma-2 Receptor/Transmembrane Protein 97 (TMEM97) and Progesterone Receptor Membrane Component 1 […]
Continue ReadingSigma-2 receptor as a potential therapeutic target for treating central nervous system disorders
by Terada K, Migita K, Matsushima Y, Kamei C. Excerpt from the article published in Neural Regen Res 2019;14:1893-4 DOI: 10.4103/1673-5374.259609 The sigma receptor (Sig-R) was first reported by Martin et al. (1976) and was initially classified into the opioid receptor family. However, Sig-R was subsequently found to differ from the opioid receptor in various studies […]
Continue ReadingSigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex
By Aladdin Riad, Chenbo Zeng, Chi-Chang Weng, Harrison Winters, Kuiying Xu, Mehran Makvandi, Tyler Metz, Sean Carlin, and Robert H. Mach Excerpt from the article published in Scientific Reports 8, 16845, 15 November 2018, DOI: https://doi.org/10.1038/s41598-018-35430-3 Editor’s Highlights The disruption of lipoprotein trafficking may also be responsible for the mechanism of action of sigma-2 receptors (TMEM97/σ2R) […]
Continue ReadingSmall molecule modulators of σ2R/Tmem97 reduce alcohol withdrawal-induced behaviors
By Luisa L. Scott, James J. Sahn, Antonio Ferragud, Rachel C. Yen, Praveen N. Satarasinghe, Michael D. Wood, Timothy R. Hodges, Ted Shi, Brooke A. Prakash, Kaitlyn M. Friese, Angela Shen, Valentina Sabino, Jonathan T. Pierce, and Stephen F. Martin Excerpt from the article published in Neuropsychopharmacol 43, 1867–1875, 20 April 2018, DOI: https://doi.org/10.1038/s41386-018-0067-z Editor’s Highlights […]
Continue ReadingCocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression
By David Aguinaga, Mireia Medrano, Ignacio Vega-Quiroga, Katia Gysling, Enric I. Canela, Gemma Navarro, and Rafael Franco Excerpt from the article published in Frontiers in Molecular Neuroscience, 12 February 2018, Sec. Molecular Signalling and Pathways, Volume 11 – 2018, DOI: https://doi.org/10.3389/fnmol.2018.00017 Editor’s Highlitghts Abstract Sigma σ1 and σ2 receptors are targets of cocaine. Despite sharing a similar name, the […]
Continue ReadingThe Sigma-2 Receptor Selective Agonist Siramesine (Lu 28-179) Decreases Cocaine-Reinforced Pavlovian Learning and Alters Glutamatergic and Dopaminergic Input to the Striatum
By Anna M. Klawonn, Anna Nilsson, Carl F. Rådberg, Sarah H. Lindström, Mia Ericson, Björn Granseth, David Engblom, and Michael Fritz Excerpt from the article published in Frontiers in Pharmacology, 10 October 2017, Sec. Experimental Pharmacology and Drug Discovery, Volume 8 – 2017, DOI: https://doi.org/10.3389/fphar.2017.00714 Editor’s Highlights Abstract Drug addiction is a chronic, debilitating disease that […]
Continue ReadingSigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice
By James J Sahn, Galo L Mejia, Pradipta R Ray, Stephen F Martin, and Theodore J Price Excerpt from the article published in ACS chemical neuroscience, 2017 Aug 16;8(8):1801-1811. DOI: https://doi.org/10.1021/acschemneuro.7b00200 Free PMC article Editor’s Highlights Abstract Neuropathic pain is an important medical problem with few effective treatments. The sigma 1 receptor (σ1R) is known to be […]
Continue ReadingSmall molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer’s disease
By Bitna Yi, James J. Sahn, Pooneh Memar Ardestani, Andrew K. Evans, Luisa L. Scott, Jessica Z. Chan, Sangeetha Iyer, Ashley Crisp, Gabriella Zuniga, Jonathan T. Pierce, Stephen F. Martin, and Mehrdad Shamloo Excerpt from the article published in Journal of Neurochemistry, 07 December 2016, 140: 561-575. DOI: https://doi.org/10.1111/jnc.13917 Editor’s Highlights Abstract Accumulating evidence suggests that […]
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