Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1
By W. Christopher Risher, Namsoo Kim, Sehwon Koh, Ji-Eun Choi, Petar Mitev, Erin F. Spence, Louis-Jan Pilaz, Dongqing Wang, Guoping Feng, Debra L. Silver, Scott H. Soderling, Henry H. Yin, and Cagla Eroglu Excerpt from the article published in Journal of Cell Biology (2018) 217 (10): 3747–3765.https://doi.org/10.1083/jcb.201802057 Editor’s Highlights The thrombospondin (TSP) family of extracellular […]
Continue ReadingAlpha2delta-1 in SF1+ Neurons of the Ventromedial Hypothalamus Is an Essential Regulator of Glucose and Lipid Homeostasis
By Jennifer A. Felsted, Cheng-Hao Chien, Dongqing Wang, Micaella Panessiti, Dominique Ameroso, Andrew Greenberg, Guoping Feng, Dong Kong, and Maribel Rios Excerpt from the article published in Cell Reports, volume 21, issue 10, P2737-2747, December 2017, DOI: https://doi.org/10.1016/j.celrep.2017.11.048 Editor’s Highlights Alpha2delta-1 (α2δ-1) plays a chief role in energy and glucose balance control acting downstream of brain-derived neurotrophic […]
Continue ReadingThe α2δ Subunit and Absence Epilepsy: Beyond Calcium Channels?
By Roberta Celli, Ines Santolini, Michela Guiducci, Gilles van Luijtelaar, Pasquale Parisi, Pasquale Striano, Roberto Gradini, Giuseppe Battaglia, Richard T. Ngomba, and Ferdinando Nicoletti Excerpt from the article published in Current Neuropharmacology 2017 Aug; 15(6): 918–925. Published online 2017 Aug. doi: 10.2174/1570159X15666170309105451 Editor’s Highlights Chilhood and juvenile absence epilepsy belongs to a group of epileptic syndromes of genetic origin […]
Continue Reading