Role of the Ca2+ channel α2δ-1 auxiliary subunit in proliferation and migration of human glioblastoma cells
By Miriam Fernández-Gallardo, Alejandra Corzo-Lopez, David Muñoz-Herrera, Margarita Leyva-Leyva, Ricardo González-Ramírez, Alejandro Sandoval, Rodolfo Delgado-Lezama, Eduardo Monjaraz, and Ricardo Felix Excerpt from the article published in PLoS ONE 17(12): e0279186, December 15, 2022, DOI: https://doi.org/10.1371/journal.pone.0279186 Editor’s Highlights Abstract The overexpression of α2δ-1 is related to the development and degree of malignancy of diverse types of […]
Continue ReadingNeurexin1α knockout rats display oscillatory abnormalities and sensory processing deficits back-translating key endophenotypes of psychiatric disorders
By Philipp Janz, Marie Bainier, Samuel Marashli, Philipp Schoenenberger, Miguel Valencia, and Roger L. Redondo Excerpt from the article published in Translational Psychiatry volume 12, Article number: 455, 28 October 2022, DOI: https://doi.org/10.1038/s41398-022-02224-1 Editor’s Highlights Neurexins (NRXNs) are a large family of cell adhesion proteins that play a central role in synapse maturation and organization […]
Continue ReadingCalcium channel α2δ1 is essential for pancreatic tumor-initiating cells through sequential phosphorylation of PKM2
By Jingtao Liu, Ming Tao, Wei Zhao, Qingru Song, Xiaodan Yang, Meng Li, Yanhua Zhang, Dianrong Xiu, and Zhiqian Zhang Journal Pre-proof to appear in Cellular and Molecular Gastroenterology and Hepatology. Accepted Date: 7 October 2022. DOI: https://doi.org/10.1016/j.jcmgh.2022.10.006 Abstract Background & Aims Tumor-initiating cells (TICs) drive pancreatic cancer tumorigenesis, therapeutic resistance and metastasis. However, TICs […]
Continue ReadingAstrocytes: the neglected stars in the central nervous system and drug addiction
By Wenjun Chen, Shiqiu Meng, Ying Han, and Jie Shi Excerpt from the article published in Medical Review, vol. , no. , 2022. Published online: June 29, 2022 DOI: https://doi.org/10.1515/mr-2022-0006 Editor’s Highlights The star-shaped astrocyte, one dominant type of glia, has been implicated in myriad biological processes of the central nervous system (CNS) by interacting […]
Continue ReadingDivergent Ca2+/calmodulin feedback regulation of CaV1 and CaV2 voltage-gated calcium channels evolved in the common ancestor of Placozoa and Bilateria
By Julia Gauberg, Wassim Elkhatib, Carolyn L. Smith, Anhadvir Singh, and Adriano Senatore Excerpt from the article published in Journal of Biological Chemistry, volume 298, 4, 101741, April 2022, DOI: https://doi.org/10.1016/j.jbc.2022.101741 Editor’s Highlights Voltage-gated calcium (CaV) channels belong to a vast eukaryotic lineage of four-domain channels, which in animals includes voltage-gated sodium (NaV) and NALCN sodium leak channels. […]
Continue ReadingCalcium current modulation by the γ1 subunit depends on alternative splicing of CaV1.1
By Yousra El Ghaleb, Nadine J. Ortner, Wilfried Posch, Monica L. Fernández-Quintero, Wietske E. Tuinte, Stefania Monteleone, Henning J. Draheim, Klaus R. Liedl, Doris Wilflingseder, Jörg Striessnig, Petronel Tuluc, Bernhard E. Flucher, and Marta Campiglio Excerpt from the article published by Journal of General Physiology, 5 September 2022; 154 (9): e202213182. DOI: https://doi.org/10.1085/jgp.202113028 Editor’s Highlights CaV1.1 […]
Continue ReadingBiallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathy
By Shehrazade Dahimene, Leonie von Elsner, Tess Holling, Lauren S. Mattas, Jess Pickard, Davor Lessel, Kjara S. Pilch, Ivan Kadurin, Wendy S. Pratt, Igor B. Zhulin, Hongzheng Dai, Maja Hempel, Maura R. Z. Ruzhnikov, Kerstin Kutsche, Annette C. Dolphin Excerpt from the article published in Brain, awac081, https://doi.org/10.1093/brain/awac081 Editor’s Highlights Bi-allelic variants in CACNA2D1, encoding alpha2delta-1 […]
Continue ReadingPost-Translational Modification of Cav1.2 and its Role in Neurodegenerative Diseases
By Yun Li, Hong Yang, Tianhan He, Liang Zhang, and Chao Liu Excerpt from the article published in Frontiers in Pharmacology, volume 12, 17 January 2022 , DOI: https://doi.org/10.3389/fphar.2021.775087 Editor’s Highlights Cav1.2, encoded by the CACNA1C gene, is a high-voltage-activated (HVA), long-lasting (L-type), and dihydropyridine (DHP)-sensitive calcium channel. Cav1.2 plays important roles in the cardiovascular system, the […]
Continue ReadingAlterations in Excitatory and Inhibitory Synaptic Development Within the Mesolimbic Dopamine Pathway in a Mouse Model of Prenatal Drug Exposure
By Taylor Boggess, James C. Williamson, Ethan B. Niebergall, Hannah Sexton, Anna Mazur, Richard D. Egleton, Lawrence M. Grover, and W. Christopher Risher Excerpt from the article published in Frontiers in Pediatrics , 9, 13 December 2021, DOI: https://doi.org/10.3389/fped.2021.794544 Editor’s Highlights Neonatal abstinence syndrome (NAS) is a collection of signs and symptoms commonly observed in […]
Continue ReadingThe Sigma-1 Receptor and the HINT1 Protein Control Alpha2Delta-1 Binding to Glutamate NMDA Receptors: Implications in Neuropathic Pain
by Rodríguez-Muñoz M, Cortés-Montero E, Onetti Y, Sánchez-Blázquez P, Garzón-Niño J. Excerpt from the article published in Biomolecules. 2021 Nov 12;11(11):1681. doi: 10.3390/biom11111681. PMID: 34827679; PMCID: PMC8615847. Editor’s Highlights Abstract Nerve injury produces neuropathic pain through the binding of α2δ1 proteins to glutamate N-methyl-D-aspartate receptors (NMDARs). Notably, mice with a targeted deletion of the sigma 1 […]
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