Transmembrane protein 97 exhibits oncogenic properties via enhancing LRP6-mediated Wnt signaling in breast cancer
By Huifang Zhu, Zijie Su, Jiong Ning, Liang Zhou, Lifeng Tan, Sapna Sayed, Jiaxing Song, Zhongyuan Wang, Huan Li, Qi Sun, Shanshan Liu, Ou Sha, Feng Leng, Xianxiong Chen & Desheng Lu Excerpt from the article published in Cell Death & Disease 12, 912 (2021). https://doi.org/10.1038/s41419-021-04211-8 Editor’s Highlights Triple-negative breast cancer (TNBC), negative for estrogen receptor (ER), […]
Continue ReadingMethamphetamine induces cardiomyopathy by Sigmar1 inhibition-dependent impairment of mitochondrial dynamics and function
By Chowdhury S. Abdullah, Richa Aishwarya, Shafiul Alam, Mahboob Morshed, Naznin Sultana Remex, Sadia Nitu, Gopi K. Kolluru, James Traylor, Sumitra Miriyala, Manikandan Panchatcharam, Brandon Hartman, Judy King, Mohammad Alfrad Nobel Bhuiyan, Sunitha Chandran, Matthew D. Woolard, Xiuping Yu, Nicholas E. Goeders, Paari Dominic, Connie L. Arnold, Karen Stokes, Christopher G. Kevil, A. Wayne Orr, […]
Continue ReadingPresynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin
By Julie Bruyère, Yah-Se Abada, Hélène Vitet, Gaëlle Fontaine, Jean-Christophe Deloulme, Aurélia Cès, Eric Denarier, Karin Pernet-Gallay, Annie Andrieux, Sandrine Humbert, Marie-Claude Potier, Benoît Delatour, and Frédéric Saudou Excerpt from the article published in eLife, May 26, 2020, DOI: https://doi.org/10.7554/eLife.56371 Editor’s Highlights Huntingtin (HTT), the scaffolding protein involved in Huntington’s disease, regulates neuritic transport of amyloid […]
Continue ReadingNO1, a New Sigma 2 Receptor/TMEM97 Fluorescent Ligand, Downregulates SOCE and Promotes Apoptosis in the Triple Negative Breast Cancer Cell Lines
By Carlos Cantonero, Pedro Javier Camello, Carmen Abate, Francesco Berardi, Gines Maria Salido, Juan Antonio Rosado, and Pedro C. Redondo Excerpt from the article published in Cancers 12, no. 2: 257. 21 January 2020, DOI https://doi.org/10.3390/cancers12020257 Editor’s Highlights Cancer cell proliferation results from a dysregulated cell cycle and an impaired cell-death signaling mechanism, where changes in […]
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