Single cocaine exposure attenuates the intrinsic excitability of CRH neurons in the ventral BNST via Sigma-1 receptors
By Jintao Wu and Yue Zhao Excerpt from the article published in Translational Neuroscience, vol. 15, no. 1, April 24, 2024, pp. 20220339. DOI: https://doi.org/10.1515/tnsci-2022-0339 Abstract The ventral bed nucleus of the stria terminalis (vBNST) plays a key role in cocaine addiction, especially relapse. However, the direct effects of cocaine on corticotropin-releasing hormone (CRH) neurons […]
Continue ReadingSigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels
By Hui Ma, Jin-feng Li, Xin Qiao, Yue Zhang, Xiao-juan Hou, Hai-xia Chang, Hong-lei Chen, Yong Zhang, and Yun-feng Li Excerpt from the article published in Acta Pharmacologica Sinica 45, 704–713 (2024). DOI: https://doi.org/10.1038/s41401-023-01201-8 Abstract Sigma-1 receptor (S1R) is a unique multi-tasking chaperone protein in the endoplasmic reticulum. Since S1R agonists exhibit potent antidepressant-like activity, […]
Continue ReadingGut microbiota-derived short-chain fatty acids ameliorate methamphetamine-induced depression- and anxiety-like behaviors in a Sigmar-1 receptor-dependent manner
By Kaikai Zhang, Lijian Chen, Jianzheng Yang, Jiali Liu, Jiahao Li, Yi Liu, Xiuwen Li, Long Chen, Clare Hsu, Jiahao Zeng, Xiaoli Xie, and Qi Wanga Excerpt from the article published in Acta Pharm Sin B. 2023 Dec;13(12):4801-4822. Epub 2023 Sep 21. PMID: 38045052; PMCID: PMC10692394. DOI: 10.1016/j.apsb.2023.09.010 Editor’s Highlights Abstract Methamphetamine (Meth) abuse can […]
Continue ReadingSigma-1 receptor and seizures
By Edijs Vavers, Liga Zvejniece, and Maija Dambrova Excerpt from the article published in Pharmacological Research, Volume 191, May 2023, 106771, ISSN 1043-6618, DOI: https://doi.org/10.1016/j.phrs.2023.106771. Editor’s Highlights Abstract Over the last decade, sigma-1 receptor (Sig1R) has been recognized as a valid target for the treatment of seizure disorders and seizure-related comorbidities. Clinical trials with Sig1R […]
Continue ReadingGender and Neurosteroids: Implications for Brain Function, Neuroplasticity, and Rehabilitation
By Loredana Raciti, Caterina Formica, Gianfranco Raciti, Angelo Quartarone, and Rocco Salvatore Calabrò Excerpt from the article published in the International Journal of Molecular Sciences. 2023; 24(5):4758. 1 March 2023. DOI: https://doi.org/10.3390/ijms24054758 Editor’s Highlights Abstract Neurosteroids are synthesized de novo in the nervous system; they mainly moderate neuronal excitability, and reach target cells via the […]
Continue ReadingThe Sigma-2 Receptor / Transmembrane protein 97 (σ2R/TMEM97) Modulator JVW-1034 Reduces Heavy Alcohol Drinking and Associated Pain States in Male Mice
By Sema G. Quadir, Sean M. Tanino, Christian D. Rohl, James J. Sahn, Emily J. Yao, Luíza dos Reis Cruz, Pietro Cottone, Stephen F. Martin, and Valentina Sabino Excerpt from the article published in Neuropharmacology, Volume 184, 108409, 15 February 2021. DOI: https://doi.org/10.1016/j.neuropharm.2020.108409. Author manuscript available at NCBI HHS public access: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856185/ Editor’s Highlights Abstract Alcohol Use Disorder […]
Continue ReadingSmall molecule modulators of σ2R/Tmem97 reduce alcohol withdrawal-induced behaviors
By Luisa L. Scott, James J. Sahn, Antonio Ferragud, Rachel C. Yen, Praveen N. Satarasinghe, Michael D. Wood, Timothy R. Hodges, Ted Shi, Brooke A. Prakash, Kaitlyn M. Friese, Angela Shen, Valentina Sabino, Jonathan T. Pierce, and Stephen F. Martin Excerpt from the article published in Neuropsychopharmacol 43, 1867–1875, 20 April 2018, DOI: https://doi.org/10.1038/s41386-018-0067-z Editor’s Highlights […]
Continue ReadingCocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression
By David Aguinaga, Mireia Medrano, Ignacio Vega-Quiroga, Katia Gysling, Enric I. Canela, Gemma Navarro, and Rafael Franco Excerpt from the article published in Frontiers in Molecular Neuroscience, 12 February 2018, Sec. Molecular Signalling and Pathways, Volume 11 – 2018, DOI: https://doi.org/10.3389/fnmol.2018.00017 Editor’s Highlitghts Abstract Sigma σ1 and σ2 receptors are targets of cocaine. Despite sharing a similar name, the […]
Continue ReadingThe Sigma-2 Receptor Selective Agonist Siramesine (Lu 28-179) Decreases Cocaine-Reinforced Pavlovian Learning and Alters Glutamatergic and Dopaminergic Input to the Striatum
By Anna M. Klawonn, Anna Nilsson, Carl F. Rådberg, Sarah H. Lindström, Mia Ericson, Björn Granseth, David Engblom, and Michael Fritz Excerpt from the article published in Frontiers in Pharmacology, 10 October 2017, Sec. Experimental Pharmacology and Drug Discovery, Volume 8 – 2017, DOI: https://doi.org/10.3389/fphar.2017.00714 Editor’s Highlights Abstract Drug addiction is a chronic, debilitating disease that […]
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