Sigma-1 Receptor as a Protective Factor for Diabetes-Associated Cognitive Dysfunction via Regulating Astrocytic Endoplasmic Reticulum-Mitochondrion Contact and Endoplasmic Reticulum Stress
By Mengyu Du, Tao Jiang, Shuxuan He Bo Cheng, Xin Zhang, Liya Li, Lan Yang, Wei Gao, Yansong Li, and Qiang Wang Excerpt from the article published in Cells 2023, 12(1), 197; 3 January 2023, DOI: https://doi.org/10.3390/cells12010197 Editor’s Highlights Abstract The prevalence of diabetes-associated cognitive dysfunction (DACD) has increased to 13.5%. Dementia, as the most severe DACD, […]
Continue ReadingEffects of sub-chronic, in vivo administration of sigma-1 receptor ligands on platelet and aortic arachidonate cascade in streptozotocin-induced diabetic rats
By Sándor Váczi, Lilla Barna, Krisztián Laczi, Ferenc Tömösi, Gábor Rákhely, Botond Penke, Lívia Fülöp, Ferenc Bogár, Tamás Janáky, Mária A. Deli, and Zsófia Mezei Excerpt from the article published in Plos One on November 17, 2022, DOI: https://doi.org/10.1371/journal.pone.0265854 Editor’s Highlights Abstract Background: Diabetes mellitus is a chronic metabolic disorder which induces endothelial dysfunction and […]
Continue ReadingDifferential Responses to Sigma-1 or Sigma-2 Receptor Ablation in Adiposity, Fat Oxidation, and Sexual Dimorphism
By Jing Li, Elisa Félix-Soriano, Katherine R. Wright, Hongtao Shen, Lisa A. Baer, Kristin I. Stanford, and Lian-Wang Guo Excerpt from the article published in International Journal of Molecular Sciences 23, no. 18: 10846. 16 September 2022, DOI: https://doi.org/10.3390/ijms231810846 Editor’s Highlights Obesity predisposes patients to comorbidities, including type 2 diabetes and cardiovascular disease, that significantly increase […]
Continue ReadingGPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting and -activating properties of human salivary histatin 1
By Dandan Ma, Wei Sun, Cuicui Fu, Kamran Nazmi, Enno C. I. Veerman, Richard T. Jaspers, Jan G. M. Bolscher, Floris J. Bikker, and Gang Wu Excerpt from the article published in International Journal of Oral Science volume 14, Article number: 42 (2022), 15 August 2022, DOI: https://doi.org/10.1038/s41368-022-00181-5 Editor’s Highlights The histatin (Hst) peptide family […]
Continue ReadingRoles of Transmembrane Protein 97 (TMEM97) in Adipose Tissue and Skeletal Muscle
By Masafumi Tenta, Jun Eguchi, and Jun Wada Excerpt from the article published in Acta Medica Okayama, 2022 Jun; 76 (3):235-245. DOI: 10.18926/AMO/63717 Editor’s Highlights Sarcopenic obesity, the combination of sarcopenia and obesity, is defined as reduced skeletal muscle mass and muscle strength in parallel with increased adiposity. Adipose tissue is the major site for the […]
Continue ReadingSigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms
By Zifen Xu, Yushuang Lei, Huan Qin, Shiyao Zhang, Ping Li, and Kai Yao Excerpt from the article published in International Journal of Molecular Sciences 23, no. 14: 7572. Published: 8 July 2022, DOI: https://doi.org/10.3390/ijms23147572 Editor’s Highlights The sigma-1 receptor is widely expressed in several organs, such as endocrine, immune, and reproductive tissues, the liver, kidney, […]
Continue ReadingAstrocytes: the neglected stars in the central nervous system and drug addiction
By Wenjun Chen, Shiqiu Meng, Ying Han, and Jie Shi Excerpt from the article published in Medical Review, vol. , no. , 2022. Published online: June 29, 2022 DOI: https://doi.org/10.1515/mr-2022-0006 Editor’s Highlights The star-shaped astrocyte, one dominant type of glia, has been implicated in myriad biological processes of the central nervous system (CNS) by interacting […]
Continue ReadingKSK-74: Dual Histamine H3 and Sigma-2 Receptor Ligand with Anti-Obesity Potential
By Kamil Mika, Małgorzata Szafarz, Monika Zadrożna, Barbara Nowak, Marek Bednarski, Katarzyna Szczepańska, Krzysztof Pociecha, Monika Kubacka, Noemi Nicosia, Izabela Juda, Katarzyna Kieć-Kononowicz, and Magdalena Kotańska Excerpt from the article published in International Journal of Molecular Sciences 2022 23, no. 13: 7011. Published: 24 June 2022. DOI: https://doi.org/10.3390/ijms23137011 Editor’s Highlights Ligands for H3/sigma-2 receptors promote the […]
Continue ReadingThe Link Between Energy-Related Sensations and Metabolism: Implications for Treating Fatigue
By Marco Filippi, Rainer Krähenmann, and Patrick Fissler Excerpt from the article published in Frontiers in Psychology, volume 13, 21 June 2022, DOI: https://doi.org/10.3389/fpsyg.2022.920556 Editor’s Highlights Physical exercise has been shown to improve energy-related sensations such as energetic arousal, calmness, burnout, emotional exhaustion, fatigue, and vigor. Evidence reveals a robust link between fatigue and different components […]
Continue ReadingMolecular function of Sigma-1 receptor in obesity-induced metabolic dysfunction
By Chowdhury S. Abdullah, Shafiul Alam, Richa Aishwarya, Jonette M. Green, A. Wayne Orr, Matthew D. Woolard, Aimee E. Vozelinek, Norman R. Harris, Randa S. Eshaq, Christopher G. Kevil, and Shenuarin Bhuiyan Introduction to the article published in Journal of Molecular and Cellular Cardiology, 046| VOLUME 112, P149, NOVEMBER 01, 2017, DOI: https://doi.org/10.1016/j.yjmcc.2017.07.058 Editor’s Highlights Sigma-1 receptor (Sigmar1) […]
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