Repeated inhibition of sigma-1 receptor suppresses GABAA receptor expression and long-term depression in the nucleus accumbens leading to depressive-like behaviors
By Yaoyao Qin, Weixing Xu, Kunpeng Li, Qi Luo, Xi Chen, Yue Wang, Lei Chen, and Sha Sha Excerpt from the article published in Frontiers in Molecular Neuroscience, 30 September 2022Sec. Brain Disease Mechanisms, DOI: https://doi.org/10.3389/fnmol.2022.959224 Editor’s Highlights Abstract Sigma-1 receptor (σ1R) downregulation in male mice is known to cause a depressive-like phenotype. The nucleus […]
Continue ReadingSigma-1 receptor: A potential target for the development of antidepressants
By Yu-Ming Wang, Cong-Yuan Xi, Hong-Mei Jia, Jun He, Wen-Wen Lian, Yu Yan, Wen-Ping Wang, Wei-Ku Zhang, and Jie-Kun Xua Introduction to the article in Neurochemistry International, 8 July 2022, 105390, DOI: https://doi.org/10.1016/j.neuint.2022.105390 Autor’s Highlights The expression of Sigma-1 receptor is changed in animal models of depression and patients with depression. Activation of Sigma-1 receptor […]
Continue ReadingThe Link Between Energy-Related Sensations and Metabolism: Implications for Treating Fatigue
By Marco Filippi, Rainer Krähenmann, and Patrick Fissler Excerpt from the article published in Frontiers in Psychology, volume 13, 21 June 2022, DOI: https://doi.org/10.3389/fpsyg.2022.920556 Editor’s Highlights Physical exercise has been shown to improve energy-related sensations such as energetic arousal, calmness, burnout, emotional exhaustion, fatigue, and vigor. Evidence reveals a robust link between fatigue and different components […]
Continue ReadingSigma-1 Receptors in Depression: Mechanism and Therapeutic Development
By Peng Ren, Jingya Wang, Nanxi Li, Guangxiang Li, Hui Ma, Yongqi Zhao, and Yunfeng Li Excerpt from the article published in Frontiers on Pharmacology, 16 June 2022, Sec.Neuropharmacology, DOI: https://doi.org/10.3389/fphar.2022.925879 Editor’s Highlights Depression is a mainly persistent mood disorder that negatively impacts the social, vocational and educational aspects of people’s life. Sigma-1 receptors are […]
Continue ReadingInflammatory signaling mechanisms in bipolar disorder
By Gregory H. Jones, Courtney M. Vecera, Omar F. Pinjari, and Rodrigo Machado-Vieira Excerpt from the article published in Journal of Biomedical Science 28, 45, 11 June 2021, DOI: https://doi.org/10.1186/s12929-021-00742-6 Editor’s Highlights Bipolar disorder (BD) is a highly complex, multifactorial disease with significant clinical heterogeneity, pleiotropy, and pathophysiological basis. Current first-line treatments, while helpful for […]
Continue ReadingRevisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders
by Kinga Sałaciak, Karolina Pytka Excerpt from the article published in Neuroscience & Biobehavioral Reviews Volume 132, January 2022, ISSN 0149-7634, https://doi.org/10.1016/j.neubiorev.2021.10.037. Editor’s Highlights Sigma-1 receptors are unique therapeutic targets modulating the activity of various proteins and systems in the organism. Preclinical studies reported that sigma-1 receptor expression correlates with the clinical manifestation of disease. […]
Continue ReadingInvolvement of Chaperone Sigma1R in the Anxiolytic Effect of Fabomotizole
By Mikhail V. Voronin, Yulia V. Vakhitova, Inna P. Tsypysheva, Dmitry O. Tsypyshev, Inna V. Rybina, Rustam D. Kurbanov, Elena V. Abramova, and Sergei B. Seredenin Excerpt from the article published in International Journal of Molecular Sciences 22, no. 11: 5455. https://doi.org/10.3390/ijms22115455 Editor’s Highlights Epidemiological data indicate that the global prevalence of anxiety disorders reaches 7.3%. […]
Continue ReadingChaperone Sigma1R and Antidepressant Effect
By Mikhail V. Voronin, Yulia V. Vakhitova, and Sergei B. Seredenin Excerpt from the article published in International Journal of Molecular Sciences 2020 Oct; 21(19): 7088. Published 2020 Sep 25. DOI: 10.3390/ijms21197088 Editor’s Highlights Antidepressant use is accompanied by various side effects, and about one-third of patients do not achieve remission. Sigma-1 receptor (Sigma1R) acts as a chaperone to stabilize […]
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