Sigma-1 receptor and seizures
By Edijs Vavers, Liga Zvejniece, and Maija Dambrova Excerpt from the article published in Pharmacological Research, Volume 191, May 2023, 106771, ISSN 1043-6618, DOI: https://doi.org/10.1016/j.phrs.2023.106771. Editor’s Highlights Abstract Over the last decade, sigma-1 receptor (Sig1R) has been recognized as a valid target for the treatment of seizure disorders and seizure-related comorbidities. Clinical trials with Sig1R […]
Continue ReadingGender and Neurosteroids: Implications for Brain Function, Neuroplasticity, and Rehabilitation
By Loredana Raciti, Caterina Formica, Gianfranco Raciti, Angelo Quartarone, and Rocco Salvatore Calabrò Excerpt from the article published in the International Journal of Molecular Sciences. 2023; 24(5):4758. 1 March 2023. DOI: https://doi.org/10.3390/ijms24054758 Editor’s Highlights Abstract Neurosteroids are synthesized de novo in the nervous system; they mainly moderate neuronal excitability, and reach target cells via the […]
Continue ReadingNeurexin1α knockout rats display oscillatory abnormalities and sensory processing deficits back-translating key endophenotypes of psychiatric disorders
By Philipp Janz, Marie Bainier, Samuel Marashli, Philipp Schoenenberger, Miguel Valencia, and Roger L. Redondo Excerpt from the article published in Translational Psychiatry volume 12, Article number: 455, 28 October 2022, DOI: https://doi.org/10.1038/s41398-022-02224-1 Editor’s Highlights Neurexins (NRXNs) are a large family of cell adhesion proteins that play a central role in synapse maturation and organization […]
Continue ReadingAdenosine A2A receptors control synaptic remodeling in the adult brain
By Xinli Xu, Rui O. Beleza, Francisco Q. Gonçalves, Sergio Valbuena, Sofia Alçada-Morais, Nélio Gonçalves, Joana Magalhães, João M. M. Rocha, Sofia Ferreira, Ana S. G. Figueira, Juan Lerma, Rodrigo A. Cunha, Ricardo J. Rodrigues, and Joana M. Marques Excerpt from the article published in Scientific Reports 12, 14690, 29 August 2022, DOI: https://doi.org/10.1038/s41598-022-18884-4 Editor’s […]
Continue ReadingInteractome overlap between risk genes of epilepsy and targets of anti-epileptic drugs
By Yu-Qin Lv, Xing Wang, Yu-Zhuang Jiao, Yan-Hua Wang, Na Wang, Lei Gao, and Jing-Jun Zhang Excerpt from the article published in Plos One, August 25, 2022, DOI: https://doi.org/10.1371/journal.pone.0272428 Editor’s Highlights Epilepsy is a widespread chronic nervous system disease, which affects about 70 million people all over the world. With the development of sequencing technology, […]
Continue ReadingUnderstanding the Role of Glia-Neuron Communication in the Pathophysiology of Epilepsy: A Review
By Peng Chen, Fuchao Chen, and Benhong Zhou Excerpt from the article published in Journal of Integrative Neuroscience (JIN) 2022, 21(4), 102. Published: 30 May 2022. DOI: https://doi.org/10.31083/j.jin2104102 Editor’s Highlights Epilepsy is a prevalent, chronic, and severe neurological disorder characterized by abnormal hypersynchrony of a large population of neurons. It is widely assumed that there is an […]
Continue ReadingBiallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathy
By Shehrazade Dahimene, Leonie von Elsner, Tess Holling, Lauren S. Mattas, Jess Pickard, Davor Lessel, Kjara S. Pilch, Ivan Kadurin, Wendy S. Pratt, Igor B. Zhulin, Hongzheng Dai, Maja Hempel, Maura R. Z. Ruzhnikov, Kerstin Kutsche, Annette C. Dolphin Excerpt from the article published in Brain, awac081, https://doi.org/10.1093/brain/awac081 Editor’s Highlights Bi-allelic variants in CACNA2D1, encoding alpha2delta-1 […]
Continue ReadingAlterations in Excitatory and Inhibitory Synaptic Development Within the Mesolimbic Dopamine Pathway in a Mouse Model of Prenatal Drug Exposure
By Taylor Boggess, James C. Williamson, Ethan B. Niebergall, Hannah Sexton, Anna Mazur, Richard D. Egleton, Lawrence M. Grover, and W. Christopher Risher Excerpt from the article published in Frontiers in Pediatrics , 9, 13 December 2021, DOI: https://doi.org/10.3389/fped.2021.794544 Editor’s Highlights Neonatal abstinence syndrome (NAS) is a collection of signs and symptoms commonly observed in […]
Continue ReadingEpilepsy in Neurodegenerative Diseases: Related Drugs and Molecular Pathways
By Amanda Cano, Elena Fonseca, Miren Ettcheto, Elena Sánchez-López, Itziar de Rojas, Silvia Alonso-Lana, Xavier Morató, Eliana B. Souto, Manuel Toledo, Mercè Boada, Marta Marquié, and Agustín Ruíz Excerpt from the article published in Pharmaceuticals. 2021; 14(10):1057. 18 October 2021, DOI: https://doi.org/10.3390/ph14101057 Editor’s Highlights Epilepsy affects approximately 50 million people worldwide. The massive entrance of […]
Continue ReadingAn Emerging Role for Sigma-1 Receptors in the Treatment of Developmental and Epileptic Encephalopathies
By Parthena Martin, Thadd Reeder, Jo Sourbron, Peter A. M. de Witte, Arnold R. Gammaitoni, and Bradley S. Galer Excerpt from the article published in International Journal of Molecular Sciences 22, no. 16: 8416, 5 August 2021 DOI: https://doi.org/10.3390/ijms22168416 Editor’s Highlights Developmental and epileptic encephalopathies (DEEs) are debilitating conditions characterized by recurrent pharmacoresistant seizures of multiple […]
Continue Reading