The Emerging Role of Sigma Receptors in Pain Medicine
By Joseph Pergolizzi Jr and Giustino Varrassi Excerpt from the article published in Cureus 15(7): e42626. July 28, 2023, doi:10.7759/cureus.42626 Abstract Sigma receptors are protein chaperones with the unexpected characteristic of being activated by ligand binding. As such, they represent intriguing new targets for potential drug development. As a protein chaperone, these “receptors” escort proteins from […]
Continue ReadingThe Sigma Enigma: A Narrative Review of Sigma Receptors
By Joseph Pergolizzi, Giustino Varrassi, Mark Coleman, Frank Breve, Dana K. Christo, Paul J. Christo, and Charbel Moussa Excerpt from the article published in Cureus 15(3): e35756. March 04, 2023; doi: 10.7759/cureus.35756 Abstract The sigma-1 and sigma-2 receptors were first discovered in the 1960s and were thought to be a form of opioid receptors initially. […]
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